Botox: Can Changing the pH Level Decrease Injection Pain?

A study has found that injection pain can be reduced by changing the level in the acidic solution of botulinum toxin type B (BTX-B).

Botox is a drug made from a neurotoxin produced by the bacterium Clostridium botulinum called botulinum toxin. It is used medically to treat certain muscular conditions and cosmetically remove wrinkles by temporarily paralysing muscles.

Two patients who had developed acquired resistance to botulinum toxin type A were injected with two different dilutions of BTX-B after having had their resistance to Botulinum toxin type A confirmed.

BTX-B usually has a pH of 5.6, but researchers diluted a dose with sodium bicarbonate in the syringe, immediately prior to injection, to normalise the pH to 7.5.

Researchers reviewed clinical evaluation data and used computer analysis to confirm the efficacy of the different solutions, and found that the BTX-B formula changed to pH 7.5 significantly reduced pain in the injection site.

The study was published in Dermatologic Surgery and results of the use of Botox were not compromised.